:root{--navy:#102c3d;--navy-deep:#0b2332;--navy-light:#274657;--teal:#087f81;--teal-light:#e6f4f1;--mint:#6ccabd;--ink:#183342;--muted:#687e89;--line:#dee6e8;--surface:#fff;--canvas:#f5f7f7;--amber:#96661f;--amber-light:#fcf5e6;--red:#a53c40;--shadow:0 9px 28px #1230430d;--font:Inter,"PingFang SC","Microsoft YaHei","Noto Sans SC",system-ui,-apple-system,sans-serif}*{box-sizing:border-box}body{margin:0;color:var(--ink);background:var(--canvas);font:14px/1.6 var(--font);-webkit-font-smoothing:antialiased}button,input,select,textarea{font:inherit}button,a,input,select,textarea{-webkit-tap-highlight-color:transparent}button{cursor:pointer}button:disabled{cursor:not-allowed;opacity:.45}a{color:var(--teal);text-underline-offset:3px}svg{width:20px;height:20px;fill:none;stroke:currentColor;stroke-width:1.7;stroke-linecap:round;stroke-linejoin:round;flex-shrink:0}button{transition:background .15s,border-color .15s,color .15s}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,summary:focus-visible,textarea:focus-visible,[tabindex]:focus-visible{outline:3px solid #50b6ba;outline-offset:3px}[hidden]{display:none!important}.skip-link{position:fixed;top:-80px;left:15px;z-index:1000;padding:12px 18px;background:var(--navy);color:#fff;border-radius:8px}.skip-link:focus{top:12px}.app-shell{min-height:100vh;display:grid;grid-template-columns:244px minmax(0,1fr)}.sidebar{height:100vh;position:sticky;top:0;background:var(--navy);color:#d6e2e8;display:flex;flex-direction:column;padding:32px 18px 20px;overflow-y:auto;z-index:30}.brand{display:flex;align-items:center;gap:12px;padding:0 9px 35px;color:white;text-decoration:none}.brand-symbol{display:flex;align-items:center;justify-content:center;border-radius:11px;background:#ffffff09;border:1px solid #ffffff13;width:42px;height:44px}.brand-symbol svg{width:32px;height:32px;fill:var(--mint);stroke:none}.brand-symbol .brand-outline{fill:none;stroke:var(--mint);stroke-width:1.3}.brand strong{display:block;font-size:28px;font-weight:650;line-height:1.25;letter-spacing:-1.4px}.brand-dot{color:var(--mint)}.brand small{display:block;font-size:8px;letter-spacing:1px;margin-top:5px;color:#9cb4c0;white-space:nowrap}.sidebar-label{padding:0 14px 14px;font-size:10px;letter-spacing:1.8px;color:#89a6b4;display:flex;justify-content:space-between;align-items:center}.sidebar-label span{font-size:8px;letter-spacing:.8px;border:1px solid #ffffff24;border-radius:4px;padding:1px 4px}#module-nav{display:flex;flex-direction:column;gap:5px}.nav-button{width:100%;display:flex;align-items:center;gap:12px;min-height:47px;border:0;background:none;color:#b8cbd4;border-radius:7px;text-align:left;padding:11px 13px;font-size:12px;font-weight:500;position:relative}.nav-button svg{width:19px;height:19px;color:#90acba}.nav-button:hover{background:#ffffff08;color:white}.nav-button.active{color:#fff;background:#ffffff10}.nav-button.active:before{content:"";position:absolute;left:0;top:12px;bottom:12px;border-radius:2px;width:3px;background:var(--mint)}.nav-button.active svg{color:var(--mint)}.nav-number{margin-left:auto;color:#648998;font-size:9px;font-variant-numeric:tabular-nums}.nav-button.active .nav-number{color:#9dbabf}.sidebar-note{display:flex;align-items:flex-start;gap:9px;padding:18px 12px 22px;border-top:1px solid #ffffff12;margin-top:auto;color:#a8bdc7;font-size:10px}.sidebar-note strong{font-size:11px;color:#ccdde3;font-weight:500}.sidebar-note p{margin:6px 0 0;line-height:1.8}.live-dot{width:6px;height:6px;background:var(--mint);border-radius:50%;display:inline-block;flex-shrink:0}.sidebar-note .live-dot{margin-top:6px}.main-platform{display:flex;align-items:center;justify-content:space-between;gap:6px;margin:0 4px;padding:12px 11px;border:1px solid #ffffff26;border-radius:6px;text-decoration:none;color:#e5f1f4;font-size:11px}.main-platform:hover{background:#ffffff09}.main-platform svg{width:15px;height:15px;color:var(--mint)}.sidebar-footer{margin:16px 0 0;text-align:center;font-size:9px;color:#7294a5;letter-spacing:1.3px}.main-shell{min-width:0}.topbar{display:flex;align-items:center;justify-content:space-between;min-height:68px;background:#fff;border-bottom:1px solid var(--line);padding:0 36px;gap:16px}.topbar-left,.topbar-right{display:flex;align-items:center;gap:16px}.topbar-eyebrow{font-size:9px;font-weight:650;letter-spacing:1.8px;color:#81939a}.topbar-mobile-title{display:none;font-weight:650}.connection-status{display:inline-flex;align-items:center;gap:7px;font-size:10px;color:var(--muted)}.connection-status.offline{color:var(--red)}.connection-status.offline .live-dot{background:#d18d54}.local-pill{font-size:10px;padding:4px 10px;border:1px solid #c7dedb;border-radius:4px;background:#f1f8f6;color:#437870;white-space:nowrap}.mobile-toggle{display:none!important}main{padding:32px 36px 20px;max-width:1920px;margin:auto}.page-heading{display:flex;justify-content:space-between;align-items:center;gap:24px;margin-bottom:27px}.eyebrow{font-size:9px;font-weight:650;letter-spacing:2px;color:var(--teal);line-height:1.5;margin-bottom:8px}h1{font-size:29px;line-height:1.3;margin:0 0 10px;font-weight:650;letter-spacing:-.5px}.page-heading p{margin:0;color:var(--muted);font-size:12px}.page-actions{flex-shrink:0}.button{display:inline-flex;align-items:center;justify-content:center;gap:7px;background:var(--teal);border:1px solid var(--teal);border-radius:6px;padding:9px 13px;font-size:11px;font-weight:550;color:#fff;line-height:1.5;min-height:36px;white-space:nowrap}.button:hover{background:#06696c;border-color:#06696c}.button svg{width:16px;height:16px}.button-outline{background:white;color:var(--ink);border-color:#c9d6db;padding:11px 14px}.button-outline:hover{color:var(--teal);background:#f0f8f7;border-color:#a7ccca}.button-outline #compare-count{font-size:9px;border-left:1px solid var(--line);padding-left:10px;margin-left:4px;font-variant-numeric:tabular-nums;color:var(--muted)}.button-quiet{color:#4d6976;border-color:var(--line);background:white;font-weight:500}.button-quiet:hover{background:#f4f8f8;border-color:#bccfd2;color:var(--teal)}.button-small{min-height:29px;padding:5px 11px;font-size:10px}.text-button{border:0;padding:5px;background:none;color:var(--teal);font-size:11px;line-height:1.5;border-radius:4px}.text-button:hover{background:var(--teal-light)}.icon-button{display:flex;align-items:center;justify-content:center;width:34px;height:34px;border:1px solid var(--line);border-radius:6px;background:white;color:var(--muted)}.icon-button:hover{background:var(--teal-light);color:var(--teal)}.scope-panel{display:flex;align-items:center;gap:21px;padding:18px 21px;background:#fff;border:1px solid var(--line);border-radius:9px;box-shadow:var(--shadow);position:relative;z-index:12}.scope-label{display:flex;align-items:center;gap:12px;flex-shrink:0;padding-right:25px;border-right:1px solid var(--line)}.scope-icon{display:flex;width:33px;height:33px;border-radius:7px;align-items:center;justify-content:center;background:var(--teal-light);color:var(--teal)}.scope-icon svg{width:17px;height:17px}.scope-label strong{display:block;font-size:11px;font-weight:600}.scope-label small{display:block;font-size:9px;color:var(--muted);margin-top:2px}.scope-field{display:flex;flex-direction:column;gap:5px;min-width:0}.scope-field>span{font-size:10px;font-weight:550;color:#627b86}.scope-field>span small{font-size:9px;margin-left:6px;font-weight:400;color:#8c9ba1}.scope-field select,.drug-picker-button{height:34px;border:1px solid #d8e2e4;border-radius:5px;background:#f9fbfb;font-size:11px;color:var(--ink);padding:0 10px;min-width:0}.scope-field select{max-width:100%}.disease-field{flex:1;max-width:330px}.drug-field{flex:1.25;position:relative;max-width:440px}.drug-picker-button{display:flex;align-items:center;justify-content:space-between;text-align:left;gap:12px;width:100%}.drug-picker-button span{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.drug-picker-button svg{height:14px;width:14px;color:#7a939d}.scope-reset{margin-left:auto;margin-top:16px;flex-shrink:0}.drug-picker{position:absolute;left:0;right:0;top:calc(100% + 7px);background:white;border:1px solid #bdcfd4;border-radius:8px;box-shadow:0 16px 32px #102c3d20;overflow:hidden;min-width:300px;z-index:70}.picker-search{display:flex;gap:7px;align-items:center;margin:10px;padding:6px 10px;background:#f4f8f8;border:1px solid var(--line);border-radius:5px}.picker-search svg{width:15px;height:15px;color:var(--muted)}.picker-search input{border:0;outline:0!important;background:none;min-width:0;width:100%;font-size:11px;padding:3px}.drug-options{max-height:260px;overflow:auto;padding:0 7px 7px}.drug-option{display:flex;align-items:center;gap:9px;padding:8px;border-radius:5px;cursor:pointer;line-height:1.4}.drug-option:hover{background:#f1f7f6}.drug-option input{accent-color:var(--teal);width:15px;height:15px}.drug-option>span{font-size:11px}.drug-option small{display:block;font-size:9px;color:var(--muted);margin-top:3px}.picker-footer{display:flex;align-items:center;gap:7px;border-top:1px solid var(--line);padding:10px;background:#fcfdfd}.picker-footer>span{font-size:9px;color:var(--muted);margin-right:auto}.picker-footer .text-button{font-size:9px}.selected-drug-chips{display:flex;gap:7px;flex-wrap:wrap;margin-top:10px}.drug-chip{display:inline-flex;align-items:center;gap:7px;border:1px solid #d3e5e1;border-radius:5px;background:#eef7f4;color:#416e69;font-size:10px;padding:4px 8px}.drug-chip button{background:none;border:0;padding:0;color:inherit;font-size:15px;line-height:1}.summary-grid{display:grid;grid-template-columns:1fr 1.05fr 1.1fr 1.3fr;gap:14px;margin:21px 0}.summary-card{display:flex;align-items:flex-start;gap:13px;padding:19px 16px;background:white;border:1px solid var(--line);border-radius:8px;min-width:0}.summary-icon{width:31px;height:31px;display:flex;align-items:center;justify-content:center;border-radius:7px;color:#5a7b8d;background:#eff4f6;flex-shrink:0}.summary-icon svg{width:17px;height:17px}.summary-card>div{min-width:0}.summary-card small{display:block;font-size:9px;color:var(--muted);margin-bottom:5px}.summary-card strong{display:block;font-size:15px;font-weight:600;line-height:1.3;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.summary-card:first-child strong{font-size:24px;font-variant-numeric:tabular-nums;letter-spacing:-.6px;line-height:1.1}.summary-card span:not(.summary-icon){display:block;font-size:9px;color:#8798a0;margin-top:6px}.summary-card.trust-card{background:#eef5f4;border-color:#d4e4e0}.trust-card .summary-icon{background:#e0eeea;color:var(--teal)}.trust-card strong{font-size:12px}.trust-card span:not(.summary-icon){color:#69877e}.content-panel{background:white;border:1px solid var(--line);border-radius:9px;box-shadow:var(--shadow);overflow:hidden}.entity-tabs{display:flex;gap:24px;padding:0 22px;border-bottom:1px solid var(--line);overflow-x:auto;scrollbar-width:thin;background:#fff;min-height:51px}.entity-tab{background:none;border:0;border-bottom:2px solid transparent;white-space:nowrap;border-radius:0;padding:15px 0 13px;color:#798e98;font-size:11px;position:relative}.entity-tab:hover{color:var(--teal)}.entity-tab.active{border-bottom-color:var(--teal);color:var(--teal);font-weight:650}.entity-context{margin:17px 22px 0;padding:10px 12px;border-radius:5px;background:#f4f8f9;border-left:2px solid #7ba5b2;color:#587887;font-size:10px;line-height:1.7}.entity-context strong{font-weight:600;color:#315669}.entity-context .context-secondary{color:#7a909a}.data-toolbar{display:flex;align-items:center;justify-content:space-between;gap:15px;padding:20px 22px 16px}.table-heading{display:flex;align-items:center;gap:8px;min-width:0}.table-heading h2{font-size:13px;font-weight:650;margin:0;white-space:nowrap}.result-count{padding:1px 6px;color:#63838e;background:#f0f5f6;border-radius:4px;font-size:9px;white-space:nowrap}.table-tools{display:flex;gap:7px;align-items:center;min-width:0}.keyword-search{border:1px solid var(--line);border-radius:6px;background:#fbfcfc;display:flex;align-items:center;gap:7px;min-height:36px;padding-left:9px;max-width:330px;min-width:180px}.keyword-search svg{width:16px;height:16px;color:#8ca1ab}.keyword-search input{border:0;background:none;outline:0;min-width:0;max-width:215px;width:100%;font-size:10px;padding:7px 0}.search-submit{border:0;border-left:1px solid var(--line);align-self:stretch;background:none;color:#5d7d88;padding:0 10px;font-size:10px}.search-submit:hover{background:var(--teal-light)}.column-filters{padding:15px 22px;display:flex;gap:10px;align-items:flex-end;flex-wrap:wrap;border-top:1px solid #eef2f3;border-bottom:1px solid #eef2f3;background:#fafcfc}.column-filters>label{display:flex;flex-direction:column;gap:5px;width:155px;font-size:10px;color:#607c87}.column-filters input,.column-filters select{min-width:0;width:100%;height:32px;border:1px solid #d7e1e4;border-radius:4px;background:white;padding:0 8px;font-size:10px;color:var(--ink)}.column-filters .filter-note{font-size:10px;color:var(--muted);margin:0 0 7px;flex:1}.filter-actions{display:flex;gap:6px;margin-left:auto;align-self:flex-end}.applied-filters{padding:0 22px 13px;display:flex;flex-wrap:wrap;gap:5px;align-items:center}.applied-filter{display:inline-flex;align-items:center;gap:6px;padding:3px 7px;border-radius:4px;background:#eff5f5;font-size:9px;color:#52747e;max-width:300px}.applied-filter button{background:none;border:0;padding:0;color:#76939b;line-height:1;font-size:14px}.data-notes{background:#fcf8ef;border-top:1px solid #f4ebd8;border-bottom:1px solid #f4ebd8;padding:10px 22px;font-size:10px;color:#8d7445}.data-notes p{margin:0 0 3px}.data-notes p:last-child{margin:0}.table-container{overflow-x:auto;min-height:250px;position:relative;scrollbar-width:thin}.data-table{width:100%;border-collapse:separate;border-spacing:0;text-align:left;font-size:10px;line-height:1.65;white-space:normal}.data-table th{background:#f6f9fa;border-top:1px solid #eaf0f1;border-bottom:1px solid #e2eaec;padding:10px 14px;color:#6d8490;font-weight:550;white-space:nowrap;position:sticky;top:0;z-index:1}.data-table th:first-child{padding-left:22px}.data-table td{padding:13px 14px;border-bottom:1px solid #edf1f2;min-width:90px;max-width:300px;vertical-align:top;color:#516e7c}.data-table td:first-child{padding-left:22px;font-weight:550;color:#264c5c;max-width:340px}.data-table tr:last-child td{border-bottom:0}.data-table tbody tr[data-drill]{cursor:pointer}.data-table tbody tr:hover{background:#f6fbfa}.data-table tbody tr:focus{background:#eaf5f2;outline-offset:-2px}.data-table .cell-text{display:-webkit-box;-webkit-line-clamp:3;-webkit-box-orient:vertical;overflow:hidden;word-break:break-word;min-width:50px}.data-table .cell-missing{color:#a5b2b8;font-size:9px;font-weight:400}.data-table .cell-link{display:inline-flex;align-items:center;gap:4px;font-size:10px;text-decoration:none;white-space:nowrap}.data-table .cell-link svg{width:12px;height:12px}.sort-button{display:flex;align-items:center;justify-content:space-between;gap:9px;border:0;background:none;color:inherit;padding:0;width:100%;font-size:10px;text-align:left}.sort-button svg{width:11px;height:11px;opacity:.45}.sort-button.sorted{color:var(--teal)}.sort-button.sorted svg{opacity:1}.status-badge{display:inline-block;font-size:9px;line-height:1.5;padding:2px 6px;border-radius:4px;background:#f0f4f6;color:#6f838e;white-space:normal;font-weight:400}.status-badge.verified{background:#e8f4ef;color:#43806b}.status-badge.candidate{background:#fbf1dd;color:#a07932}.status-badge.missing{background:#f0f3f4;color:#88979f}.status-badge.rejected{background:#f9edeb;color:#a56864}.table-footer{border-top:1px solid var(--line);padding:13px 22px;display:flex;align-items:center;justify-content:space-between;gap:15px;color:#8b9ba3;font-size:9px;min-height:59px}.pagination-controls{display:flex;align-items:center;gap:10px}.pagination-controls label{display:flex;align-items:center;gap:5px;margin-right:12px;white-space:nowrap}.pagination-controls select{border:1px solid var(--line);border-radius:4px;color:#69808c;font-size:10px;padding:3px 4px;background:#fff}.pagination-button{width:27px;height:27px;border:1px solid var(--line);border-radius:4px;display:flex;align-items:center;justify-content:center;background:white;color:#63818e}.pagination-button:hover{background:#edf5f4}.pagination-button svg{width:13px;height:13px}#page-number{min-width:40px;text-align:center;font-variant-numeric:tabular-nums}.loading-state,.empty-state,.error-state{display:flex;min-height:290px;align-items:center;justify-content:center;flex-direction:column;padding:35px 25px;text-align:center;gap:10px;color:#8ca0ab}.loading-state strong,.empty-state strong,.error-state strong{font-size:13px;font-weight:550;color:#527283}.loading-state>span:last-child,.empty-state>p,.error-state>p{font-size:11px;max-width:530px;margin:0;line-height:1.8}.state-icon{background:#edf4f5;border:1px solid #e1ebed;display:flex;align-items:center;justify-content:center;width:48px;height:48px;border-radius:13px;color:#7da2b0;margin-bottom:4px}.state-icon svg{width:24px;height:24px}.error-state .state-icon{background:#fbf3e8;border-color:#f3e6d4;color:#be9456}.error-state>p{color:#9b876a}.spinner{width:27px;height:27px;border:2px solid #e1edeb;border-top-color:var(--teal);border-radius:50%;animation:spin .8s linear infinite;margin-bottom:4px}@keyframes spin{to{transform:rotate(360deg)}}.page-footer{display:flex;justify-content:space-between;gap:18px;padding:23px 1px 5px;color:#9ba9b0;font-size:9px}.page-footer>span:first-child{display:flex;gap:7px;align-items:center}.footer-dot{width:5px;height:5px;background:#97b8b4;border-radius:50%;display:inline-block}.error-banner{padding:13px 16px;margin-bottom:20px;background:#fbefeb;color:#9b574d;border:1px solid #edcfc7;border-radius:7px;font-size:11px}.error-banner button{margin-left:12px}.comparison-panel{padding:24px}.comparison-top{display:flex;align-items:flex-start;justify-content:space-between;gap:20px;margin-bottom:17px}.comparison-top h2{margin:0;font-size:17px}.comparison-top p{font-size:11px;color:var(--muted);margin:7px 0 0}.compare-drug-strip{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:12px;margin-bottom:22px}.compare-drug-card{border:1px solid #d3e4e1;border-top:3px solid var(--teal);border-radius:7px;background:#f6faf9;padding:15px}.compare-drug-card strong{font-size:13px;color:#25575c}.compare-drug-card p{font-size:10px;color:var(--muted);margin:7px 0 0}.compare-section{margin-top:22px;border:1px solid var(--line);border-radius:7px;overflow:hidden}.compare-section>h3{font-size:12px;margin:0;padding:12px 16px;background:#f6f9fa;border-bottom:1px solid var(--line)}.compare-section .table-container{min-height:0;max-height:440px}.compare-section .empty-state{min-height:140px}.comparison-notes{font-size:10px;padding:12px 15px;background:#faf5e9;color:#97794b;border-radius:5px}.comparison-notes p{margin:3px 0}.cost-panel{background:white;border:1px solid var(--line);border-radius:8px;margin-top:19px}.cost-panel summary{padding:17px 21px;cursor:pointer;font-size:12px;color:#2f6271}.cost-panel summary small{font-size:10px;color:#7c929c;font-weight:400;margin-left:14px}.cost-content{padding:0 21px 20px}.cost-content>p{font-size:10px;color:var(--muted);margin:0 0 16px}.cost-inputs{display:grid;grid-template-columns:repeat(4,1fr) 1.5fr;gap:13px}.cost-inputs label{font-size:10px;color:#6b828d;display:flex;flex-direction:column;gap:6px}.cost-inputs input{width:100%;min-width:0;height:34px;border:1px solid #d6e2e5;border-radius:5px;padding:0 9px;font-size:10px;color:var(--ink)}.cost-output{padding-left:18px;border-left:1px solid var(--line)}.cost-output small{display:block;color:var(--muted);font-size:9px}.cost-output strong{display:block;color:var(--teal);font-size:15px;margin-top:7px}.cost-formula{font-size:9px;color:#859ba4;margin-top:13px}.detail-scrim{position:fixed;inset:0;background:#102c3d55;backdrop-filter:blur(1px);z-index:79}.detail-drawer{position:fixed;right:0;top:0;height:100dvh;width:min(790px,95vw);background:#fff;box-shadow:-10px 0 40px #102c3d25;z-index:80;display:flex;flex-direction:column;animation:drawer-in .2s ease-out}@keyframes drawer-in{from{transform:translateX(60px);opacity:.6}to{transform:translateX(0);opacity:1}}.drawer-top{display:flex;justify-content:space-between;align-items:flex-start;padding:25px 28px 20px;border-bottom:1px solid var(--line);gap:15px;background:#f7fafb}.drawer-top>div{min-width:0}.drawer-top h2{font-size:19px;margin:0;line-height:1.5;word-break:break-word}.drawer-top .eyebrow{font-size:8px;margin-bottom:6px}.drawer-top .icon-button{flex-shrink:0}.detail-content{overflow-y:auto;padding:24px 28px 35px}.detail-top-note{padding:11px 13px;background:#f0f6f6;border-left:2px solid #8db7b8;color:#69868d;font-size:10px;margin-bottom:20px}.detail-fields{margin:0;border:1px solid var(--line);border-radius:7px;overflow:hidden}.detail-field{display:grid;grid-template-columns:150px minmax(0,1fr);border-bottom:1px solid #edf2f3;font-size:11px}.detail-field:last-child{border:0}.detail-field dt{margin:0;background:#f7fafb;color:#718995;padding:11px 13px;word-break:break-word;font-size:10px}.detail-field dd{margin:0;padding:11px 14px;word-break:break-word;white-space:pre-wrap;line-height:1.8}.detail-field dd .cell-text{display:block}.detail-section{margin-top:25px}.detail-section h3{font-size:13px;margin:0 0 11px;color:#395f70}.detail-section .table-container{min-height:0;border:1px solid var(--line);border-radius:6px;max-height:390px}.detail-section .data-table td{padding:10px 12px;max-width:260px}.detail-section .data-table th{padding:9px 12px}.detail-section .data-table td:first-child,.detail-section .data-table th:first-child{padding-left:12px}.source-list{list-style:none;margin:0;padding:0;border:1px solid var(--line);border-radius:6px;overflow:hidden}.source-list li+li{border-top:1px solid #edf1f2}.source-list a{display:flex;align-items:center;justify-content:space-between;gap:15px;padding:11px 13px;font-size:11px;text-decoration:none;background:#fcfdfd;word-break:break-word}.source-list a:hover{background:#f0f8f7}.source-list svg{width:14px;height:14px}.detail-notes{font-size:10px;line-height:1.8;color:#8c744c;padding:11px 13px;background:#fcf7ec;border-radius:5px}.detail-notes p{margin:0 0 5px}.detail-notes p:last-child{margin:0}.annotation-panel{margin-top:26px;border:1px solid #cbded9;border-radius:7px;background:#f7fbfa;overflow:hidden}.annotation-header{display:flex;justify-content:space-between;gap:10px;padding:13px 15px;border-bottom:1px solid #e0ebe7}.annotation-header h3{font-size:12px;margin:0;color:#356d65}.annotation-header span{font-size:9px;color:#7e9b91}.annotation-body{padding:15px}.annotation-body>p{font-size:10px;color:#7d958a;line-height:1.7;margin:0 0 13px}.annotation-body textarea{width:100%;min-height:100px;padding:10px 11px;resize:vertical;border:1px solid #cfdfda;border-radius:5px;font-size:11px;line-height:1.8;color:var(--ink);background:white}.annotation-actions{display:flex;align-items:center;gap:10px;margin-top:11px}.annotation-actions select{padding:6px 8px;background:#fff;border:1px solid #cfdfda;border-radius:5px;font-size:10px;color:#628175}.annotation-actions .button{margin-left:auto}.annotation-message{font-size:10px;color:#718d81;margin-top:9px;min-height:17px}.annotation-message.error{color:var(--red)}.annotation-history{border-top:1px solid #dce9e3;padding:12px 15px;font-size:10px;color:#6e8c7e}.annotation-history p{margin:4px 0;white-space:pre-wrap;word-break:break-word}.annotation-history small{color:#8da398;font-size:9px}.annotation-history strong{font-weight:550}.annotation-history details{padding-bottom:7px}.annotation-history summary{cursor:pointer;color:#719082;font-size:10px}.detail-back{display:flex;align-items:center;gap:6px;margin-bottom:13px}.detail-back svg{width:13px;height:13px}.toast{position:fixed;left:50%;bottom:27px;transform:translateX(-50%);z-index:100;background:var(--navy);color:#f5ffff;border:1px solid #50717f;border-radius:7px;padding:11px 18px;font-size:11px;max-width:min(600px,90vw);box-shadow:0 6px 25px #102c3d24}.nav-scrim{position:fixed;inset:0;background:#102c3d77;border:0;border-radius:0;z-index:28}.body-locked{overflow:hidden}.no-filter-message{font-size:10px;color:var(--muted)}.mono-text{font-family:ui-monospace,SFMono-Regular,Consolas,monospace;font-size:10px}.inline-link{color:var(--teal);word-break:break-all}.detail-caption{font-size:9px;color:#8ba0a9;margin-top:8px}.empty-filter-clear{margin-top:4px}.section-label-count{font-size:9px;color:#88a0ab;font-weight:400;margin-left:6px}
@media(min-width:1600px){.sidebar{padding-top:37px}.topbar{min-height:76px}main{padding:40px 46px 24px}.summary-card{padding:22px}.scope-panel{padding:20px 24px}.data-toolbar{padding-top:23px;padding-bottom:20px}.data-table{font-size:11px}.data-table th,.sort-button{font-size:11px}.data-table td{padding-top:15px;padding-bottom:15px}.nav-button{min-height:51px;font-size:13px}.brand strong{font-size:31px}.page-heading h1{font-size:32px}}
@media(max-width:1250px){.app-shell{grid-template-columns:218px minmax(0,1fr)}.sidebar{padding-left:12px;padding-right:12px}.brand{gap:9px;padding-left:8px;padding-right:4px}.brand-symbol{width:37px;height:40px}.brand strong{font-size:25px}.brand small{font-size:7px}.nav-button{gap:9px;font-size:11px;padding-left:11px;padding-right:8px}.topbar{padding-left:25px;padding-right:25px}main{padding:27px 25px 18px}.summary-grid{gap:10px;grid-template-columns:1fr 1fr 1fr}.trust-card{display:none}.scope-panel{gap:15px;padding:16px}.scope-label{padding-right:16px}.scope-label small{font-size:8px}.scope-label strong{font-size:10px}.scope-icon{display:none}.scope-reset{font-size:10px}.data-toolbar{flex-wrap:wrap;gap:12px}.table-tools{margin-left:auto}.table-heading{flex:1}.keyword-search{max-width:280px;min-width:170px}.keyword-search input{width:150px}.table-tools>.button{padding:8px 9px;font-size:10px}.cost-inputs{grid-template-columns:repeat(4,1fr)}.cost-output{grid-column:1/-1;border-left:0;border-top:1px solid var(--line);padding:13px 0 0;display:flex;align-items:center;justify-content:space-between}.cost-output strong{margin:0}.topbar-eyebrow{font-size:8px;letter-spacing:1.3px}.connection-status{font-size:9px}}
@media(max-width:980px){.app-shell{grid-template-columns:195px minmax(0,1fr)}.sidebar{padding-left:9px;padding-right:9px}.brand{gap:7px}.brand-symbol{width:32px;height:35px}.brand-symbol svg{width:28px;height:28px}.brand strong{font-size:23px}.brand small{font-size:6px;letter-spacing:.6px}.nav-button{font-size:10px;gap:7px}.nav-button svg{width:17px;height:17px}.nav-number{font-size:8px}.sidebar-label{font-size:9px;padding-left:10px}.sidebar-note{padding-left:9px;font-size:9px}.main-platform{font-size:10px;padding:10px 8px}.topbar{padding:0 22px}.topbar-eyebrow{display:none}.topbar-mobile-title{display:block;font-size:12px}.topbar-right{gap:10px}main{padding:24px 22px 15px}.page-heading{gap:15px}.page-heading p{font-size:11px}h1{font-size:25px}.button-outline{font-size:10px;padding:10px}.scope-panel{gap:13px;flex-wrap:wrap}.scope-label{width:100%;border-right:0;border-bottom:1px solid var(--line);padding:0 0 9px;gap:8px}.scope-label small{display:inline;margin-left:9px}.scope-label>div{display:flex;align-items:baseline}.scope-reset{position:absolute;top:10px;right:12px;margin:0}.disease-field{max-width:none;flex:1}.drug-field{max-width:none;flex:1.1}.summary-card{padding:15px 13px;gap:9px}.summary-icon{width:25px;height:27px}.summary-icon svg{width:15px;height:15px}.summary-card strong{font-size:12px}.summary-card:first-child strong{font-size:21px}.summary-card small{font-size:8px}.summary-card span:not(.summary-icon){font-size:8px}.table-tools{width:100%;margin:0}.keyword-search{flex:1;max-width:none}.keyword-search input{width:100%;max-width:none}.entity-tabs{gap:20px;padding:0 18px}.entity-tab{font-size:10px}.data-toolbar{padding:17px 18px 14px}.entity-context{margin:14px 18px 0}.table-footer{padding-left:18px;padding-right:18px}.page-footer{font-size:8px;flex-direction:column;gap:7px}.column-filters{padding:13px 18px}.column-filters>label{width:calc(50% - 5px)}.filter-actions{width:100%;margin-top:3px;justify-content:flex-end}.table-container{min-height:230px}.loading-state,.empty-state,.error-state{min-height:250px}.pagination-controls{gap:7px}.pagination-controls label{margin-right:5px}.cost-inputs{grid-template-columns:repeat(2,1fr)}}
@media(max-width:720px){.app-shell{display:block}.sidebar{position:fixed;left:0;top:0;width:244px;height:100dvh;transform:translateX(-100%);transition:transform .2s ease}.sidebar.open{transform:translateX(0)}.sidebar .brand strong{font-size:28px}.sidebar .brand small{font-size:8px;letter-spacing:.8px}.sidebar .brand-symbol{width:42px;height:44px}.sidebar .nav-button{font-size:12px;gap:12px;min-height:48px}.sidebar .nav-number{font-size:9px}.sidebar .sidebar-label{font-size:10px}.sidebar .main-platform{font-size:11px;padding:12px}.sidebar-note{font-size:10px}.topbar{height:60px;min-height:60px;padding:0 17px}.mobile-toggle{display:flex!important;width:29px;height:29px;border:0}.mobile-toggle svg{width:20px;height:20px}.topbar-left{gap:9px}.topbar-mobile-title{font-size:13px}.topbar-right{gap:0}.connection-status{display:none}.local-pill{font-size:9px;padding:3px 7px}main{padding:24px 16px 15px}.page-heading{margin-bottom:20px;align-items:flex-start;gap:10px}.page-heading .eyebrow{font-size:8px;letter-spacing:1.5px}.page-heading h1{font-size:25px;margin-bottom:8px}.page-heading p{font-size:10px;max-width:310px;line-height:1.8}.page-actions{margin-top:21px}.page-actions .button{padding:8px;font-size:9px;gap:5px}.page-actions .button svg{width:14px;height:14px}.page-actions #compare-count{display:none}.scope-panel{padding:14px;gap:12px;border-radius:7px}.scope-field>span{font-size:9px}.scope-field select,.drug-picker-button{font-size:10px;height:34px;padding-left:8px}.scope-label{padding-bottom:7px}.scope-label strong{font-size:10px}.scope-label small{font-size:8px}.scope-reset{top:9px;right:9px;font-size:9px}.scope-field>span small{font-size:8px}.drug-picker{left:auto;right:0;min-width:280px;max-width:calc(100vw - 60px)}.drug-options{max-height:230px}.picker-footer{gap:5px}.summary-grid{margin:17px 0;grid-template-columns:1fr 1fr;gap:9px}.summary-card{padding:14px 12px}.summary-card:nth-child(3){display:none}.summary-card strong{font-size:12px}.summary-card:first-child strong{font-size:21px}.summary-card span:not(.summary-icon){font-size:8px;line-height:1.7;margin-top:4px}.summary-card small{font-size:9px}.summary-card .summary-icon{width:27px;height:29px}.entity-tabs{padding:0 14px;gap:20px;min-height:47px}.entity-tab{padding:13px 0 12px;font-size:10px}.entity-context{margin:13px 14px 0;padding:9px 10px;font-size:9px}.data-toolbar{padding:15px 14px 13px;gap:11px}.table-heading h2{font-size:12px}.table-tools{gap:6px;flex-wrap:wrap}.keyword-search{width:100%;flex-basis:100%;min-height:35px}.keyword-search input{font-size:10px}.table-tools>.button{font-size:9px;min-height:31px;padding:6px 9px}.table-tools>.button svg{width:14px;height:14px}.table-tools>#filter-toggle{margin-left:auto}.data-table th,.sort-button{font-size:9px}.data-table td{font-size:10px;padding:11px 12px;min-width:110px;max-width:240px}.data-table th:first-child,.data-table td:first-child{padding-left:14px}.data-table th{padding:9px 12px}.table-footer{padding:12px 14px;flex-wrap:wrap;gap:9px}.table-footer>#pagination-info{font-size:8px}.pagination-controls{margin-left:auto;font-size:8px;gap:5px}.pagination-controls label{font-size:8px;gap:4px;margin:0 4px 0 0}.pagination-controls select{font-size:9px}.pagination-button{width:25px;height:25px}#page-number{min-width:32px}.column-filters{padding:12px 14px}.column-filters>label{font-size:9px}.column-filters select,.column-filters input{font-size:9px;height:31px}.applied-filters{padding:0 14px 12px}.data-notes{font-size:9px;padding:9px 14px}.loading-state,.empty-state,.error-state{min-height:260px;padding:28px 22px}.loading-state strong,.empty-state strong,.error-state strong{font-size:12px}.loading-state>span:last-child,.empty-state>p,.error-state>p{font-size:10px}.detail-drawer{width:100vw}.drawer-top{padding:20px}.drawer-top h2{font-size:17px}.detail-content{padding:19px 18px 30px}.detail-field{grid-template-columns:110px minmax(0,1fr)}.detail-field dt{padding:9px 10px;font-size:9px}.detail-field dd{padding:9px 11px;font-size:10px}.detail-section h3{font-size:12px}.annotation-header{padding:12px}.annotation-header h3{font-size:11px}.annotation-header span{font-size:8px}.annotation-body{padding:12px}.annotation-actions{gap:7px}.annotation-actions select{font-size:9px;max-width:200px}.annotation-actions .button{font-size:10px;padding:8px}.comparison-panel{padding:17px 14px}.comparison-top h2{font-size:15px}.comparison-top p{font-size:10px}.comparison-top{gap:12px}.comparison-top .button{font-size:9px;padding:7px}.compare-drug-strip{grid-template-columns:repeat(2,minmax(0,1fr));gap:8px}.compare-drug-card{padding:12px}.compare-drug-card strong{font-size:11px}.compare-drug-card p{font-size:9px}.compare-section>h3{font-size:11px}.comparison-notes{font-size:9px}.cost-panel summary{font-size:11px;padding:14px}.cost-panel summary small{display:block;font-size:9px;margin:5px 0 0 14px}.cost-content{padding:0 14px 17px}.cost-inputs label{font-size:9px}.cost-formula{font-size:8px;line-height:1.8}.cost-output strong{font-size:12px}.cost-output small{font-size:8px}.page-footer{padding-top:20px;font-size:8px}.error-banner{font-size:10px}.toast{font-size:10px;bottom:18px}.trust-card{display:none}}
@media(prefers-reduced-motion:reduce){*,*:before,*:after{animation:none!important;scroll-behavior:auto!important;transition:none!important}}
.sr-only{position:absolute!important;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}
.search-submit{white-space:nowrap;flex-shrink:0;min-width:42px}.error-banner.info{background:#edf5f5;border-color:#d4e5e3;color:#507a80}.error-banner.warning{background:#fcf6e9;border-color:#ecddbb;color:#94763d}
.column-filters{max-height:310px;overflow-y:auto}.column-filters .filter-actions{flex-basis:100%;position:sticky;bottom:-15px;background:#fafcfc;padding:8px 0 2px;justify-content:flex-end}.context-secondary{line-height:1.9}
.data-table th[data-column="title"],.data-table td[data-column="title"],.data-table th[data-column="publication_title"],.data-table td[data-column="publication_title"]{min-width:220px;width:260px;max-width:360px}.data-table td[data-column="title"] .cell-text,.data-table td[data-column="publication_title"] .cell-text{min-width:192px}
.session-controls{display:flex;align-items:center;gap:8px;padding-left:13px;border-left:1px solid var(--line)}.session-avatar{display:flex;align-items:center;justify-content:center;background:#edf4f4;color:#4c7c84;width:28px;height:28px;border-radius:50%}.session-avatar svg{height:16px;width:16px}.session-copy strong{display:block;font-size:10px;line-height:1.4;max-width:115px;overflow:hidden;text-overflow:ellipsis}.session-copy small{display:block;font-size:8px;color:#8ba0a9;line-height:1.5}.session-logout{background:transparent;border:0;border-radius:4px;padding:5px 4px;font-size:9px;color:#6c8791;white-space:nowrap}.session-logout:hover{color:var(--teal);background:var(--teal-light)}.auth-screen{min-height:100dvh;display:flex;align-items:center;flex-direction:column;justify-content:center;padding:45px 20px;background:radial-gradient(ellipse at 50% 25%,#1a4c5c 0%,#102c3d 45%,#0b2332 100%);color:white}.auth-brand{display:flex;align-items:center;justify-content:center;gap:11px;flex-wrap:wrap;margin-bottom:30px}.auth-brand-mark{font-size:25px;line-height:1;font-weight:650;letter-spacing:-2px;color:var(--mint);border:1px solid #ffffff24;border-radius:8px;padding:9px 12px 13px;background:#ffffff06}.auth-brand strong{font-size:20px;font-weight:550;letter-spacing:.6px}.auth-brand>span:last-child{flex-basis:100%;text-align:center;color:#91b6c0;font-size:8px;letter-spacing:3px;margin-top:2px}.auth-card{background:#fff;border:1px solid #d8e5e5;box-shadow:0 20px 90px #00131f40;color:var(--ink);width:min(500px,100%);padding:34px 38px;border-radius:12px;text-align:center}.auth-card>.eyebrow{font-size:8px;letter-spacing:2px;color:#7e9fa5;margin-bottom:21px}.auth-symbol{display:flex;align-items:center;justify-content:center;width:53px;height:53px;background:var(--teal-light);color:var(--teal);border-radius:14px;margin:0 auto 20px}.auth-symbol svg{height:27px;width:27px}.auth-card h1{font-size:22px;line-height:1.55;margin:0 0 12px}.auth-card>p{font-size:12px;line-height:1.9;color:#80959f;margin:0 auto;max-width:360px}.auth-detail{font-size:10px;color:#9a7441;line-height:1.85;margin-top:13px;white-space:pre-wrap}.auth-detail:empty{display:none}.auth-actions{display:flex;flex-direction:column;gap:9px;margin:24px 0 16px}.auth-actions .button{min-height:42px;font-size:12px}.auth-main-link{display:inline-block;font-size:10px;color:#749299;text-decoration:none;margin-top:2px}.auth-main-link:hover{color:var(--teal)}.auth-footer{font-size:9px;letter-spacing:1px;color:#8eadb8;margin-top:23px}.access-restriction{padding:11px 15px;background:#f4f7f8;border:1px solid #e0e8ea;border-radius:5px;color:#7c919b;font-size:10px;margin-top:20px}.local-pill.public{background:#eef4f8;border-color:#d3e0e9;color:#5f7f94}
@media(max-width:980px){.topbar-right{gap:9px}.session-controls{padding-left:9px;gap:6px}.session-copy strong{max-width:83px}.session-copy small{font-size:7px}}
@media(max-width:720px){.session-controls{padding-left:8px;margin-left:9px;gap:5px}.session-avatar{display:none}.session-copy strong{font-size:9px;max-width:83px}.session-copy small{font-size:7px}.session-logout{font-size:8px;padding:5px}.auth-screen{padding:30px 17px}.auth-brand{margin-bottom:24px}.auth-brand strong{font-size:17px}.auth-card{padding:28px 24px}.auth-card h1{font-size:20px}.auth-card>p{font-size:11px}.auth-actions .button{font-size:11px}.auth-footer{font-size:8px;letter-spacing:.4px}}
.login-card{padding-top:29px;padding-bottom:26px}.login-card .auth-symbol{margin-bottom:15px;width:47px;height:47px}.login-card .eyebrow{margin-bottom:18px}.login-form{text-align:left;margin-top:22px}.login-form>label{display:flex;flex-direction:column;gap:7px;margin-top:14px;font-size:11px;color:#54717f;font-weight:550}.login-form input{height:42px;border:1px solid #ccdadf;border-radius:6px;padding:0 12px;background:#fbfdfd;color:var(--ink);font-size:12px;min-width:0;width:100%}.login-form input::placeholder{color:#a6b5bb;font-size:11px;font-weight:400}.login-help{font-size:9px;color:#94a6ae;font-weight:400;margin:9px 0 0}.login-submit{width:100%;margin-top:20px;min-height:43px;font-size:12px}.login-error{padding:10px 12px;margin-top:13px;background:#fcf1eb;border:1px solid #eed8cc;border-radius:5px;font-size:10px;line-height:1.8;color:#a16848}.login-retry{display:block;margin:9px auto 0;font-size:10px}.login-support{display:flex;align-items:center;justify-content:center;gap:13px;font-size:10px;margin:18px 0 15px}.login-support a{text-decoration:none;color:#658995}.login-support a:hover{color:var(--teal)}.login-support span{color:#c5d4d9}.login-screen .auth-card>p{font-size:11px}
.cell-restricted{color:#9aabb2;font-size:9px;font-weight:400;white-space:nowrap}.login-error:focus-visible{outline:2px solid #d2a280;outline-offset:3px}

.registration-link{color:inherit;text-decoration:none;white-space:nowrap}.registration-link:hover{text-decoration:underline}
.registration-link{font-size:11px;line-height:1.7}.auth-footer .registration-link{color:#bdd8df}